DESARROLLO DE MODELO MURINO DE COLONIZACIÓN DE Lactobacillus plantarum LP5 DE ORIGEN PORCINO

The objective of this work was to generate an experimental model colonization by L. plantarum LP5 in mice (Mus musculus) aimed at improving the general state animal and preventing possible presence zoonotic pathogens. used were females Balb/cCmedc strain, 6 weeks old. Animals organized into 2 groups 3 individuals: treated (GT) control (GC). GT administered twice weekly gavage with 100 µl rifampicin resistant porcine a concentration 1010 CFU. Mice fed water food ad libitum throughout experiment. Colonization both evaluated clinical signs microbiological analysis feces. Sampling performed intervals quantify populations supplied LP5, Lactobacillus spp., Escherichia coli, total coliforms, Campylobacter yeast. results sampling week showed recovery above 5 logUFC/g, second it 7 logUFC/g third logUFC/g. CG, meanwhile, maintained null count that there no imbalance between microbial components. Therefore, is feasible affirm inoculum did not alter balance intestinal ecosystem. Particularly, exert inhibitory effect on members previously established microbiota.